50 Cent, Ja Rule Beef [VIDEO]: Murder Inc. Admits 'Loss' to G-Unit Rapper, Floyd Mayweather and Ray J Instagram Feud to Also Crumble? [PHOTOS]

Do fans remember Ja Rule's infamous feud with 50 Cent which led to the demise of Murder Inc? Well, the "Put It On Me" rapper finally opened-up about his "loss" to Shady/Aftermath/G-Unit Records in a revealing interview with Hot 97's Angie Martinez. Fifty's a fighter... will Floyd Mayweather and Ray J also fall victim to the rapper's constant badgering on Instagram?

According to Ja Rule, Murder Inc. was unable to properly respond to Fifty during the ongoing feud - there was just too much going on at-the-time (including the label's impending racketeering case):

"There were things that were behind-the-scenes that you don't see that made us seem more irrelevant." Rule reveals in the interview. "We couldn't go to award shows. [50's camp] would make calls like 'Well, if Murder Inc. is in the building, they are not gonna perform this year.'"

The rapper's fellow partner Irv Gotti also admitted, "We took the L... We were in my office, me and Rule right, and Flex was about to play 'In Da Club,' right? So Flex plays in the club, that was record was dope. I looked at Rule and told him, 'We have a problem.'"

Check out the full interview here:

So, how will undefeated professional boxer Floyd Mayweather, Jr. handle Fifty's insults on Instagram - will he also crumble? Mayweather and Fifty have been involved in an ongoing fued for quite some time now... and the Get Rich or Die Tryin' superstar took things up a notch earlier this week on Instagram:

50 Cent: "I GOT FLOYD, I GOT RAY J At the same damn Time."

As Mstars previously reported:

The lovely lady in this pic is known as Princess... allegedly one of Mayweather's several "infamous" girlfriends. According to MediaTakeOut.com, Princess is Mayweather's third main squeeze... coming in after fiancee Shantel and baby mama Melissa.

Fifty also posted:

50cent: "@Floydmayweather don't feel Stupid some of them belong on a TRACK that's all #smsaudio."

50cent: "THOT ALERT look at the dog Lmao #smsaudio."

50cent: "This is Floyd message to the girl lol."

50cent: "Ray j said my time is money. LMAO."

Mayweather isn't taking all of these insults sitting down... but still, it appears that Fifty won't stop until he wins!