Lil Wayne & Christina Milian 'Heartbreak' Amid Amber Rose 'Hook-Up' Buzz: 'It Is What It Is' Instagram Break-Up, Daughter Reginae Carter Happy?

Lil Wayne just can't settle-down, despite rumors that the YMCMB rapper's currently dating "Turned Up" beauty, Christina Milian. But maybe the "Dip It Low" songstress finally gave-up on securing Weezy's love after learning that he allegedly "hooked-up" with Wiz Khalifa's outspoken ex, Amber Rose...

UPDATE: Christina Milian 'Moving On' After Lil Wayne & Amber Rose Cheating Hype

But did the "Only" emcee really fool around with the infamous Hollywood socialite during a drunken stupor?

As MstarsNews previously reported:

Apparently, Rose's whirlwind romance with NBA superstar James Harden quickly ended thanks to "Love & Hip-Hop New York" starlet, Tahiry Jose. But no worries - the aspiring model seemingly rebounded with one of the hottest rappers in the game... Lil Wayne.

So, The PinkPrint sweetheart Nicki Minaj is official spokeswoman for the new wine beverage, MYX Fusion Moscato. Several celebs attended a huge bash sponsored by MYX at New York City's popular Stage 48 nightclub over the weekend.

(Instagram)

According to the infamous gossip webloid MediaTakeOut.com, several big-name stars definitely got a little tipsy on the free alcohol including Juelz Santana, Mase, members of the Young Money crew... oh - and Ms. Rose.

And following such drunken celebrations, the stunning fashionista allegedly left through a back door - with Weezy.

Apparently they tried to sneak-out, but some eyewitnesses saw them leave together.

Even juicier - Rose and 32-year-old Milian are supposedly good friends.

Wonder if the aspiring twerker will respond, considering she's clearly infatuated with her Cash Money beau?

As MTO concludes:

"Once again this is NOT RUMOR, it's fact - we may have been DRUNK OF THAT MYX MOSCATO - but not drunk enough to see Wayne leave the club with THOT IN HAND!!!"

Well, if so, Rose (and her booty) are definitely getting around...

And now Milian seems over the drama. she recently shared this cryptic post on Instagram:

christinamilian: "And that's it I guess sometimes #itiswhatitis."

And she continues spending more quality time with BFF, Karrueche Tran. Maybe for some "bestie" support:

christinamilian: "Fly Girl Unite. we're always having a good time living life."

So is Milian's infatuation with Tunechi official dead? The rapper's 16-year-old daughter Reginae Carter was never a fan of her dad dating the "Love Don't Cost A Thing" starlet, so she's probably happy if the break-up rumors are indeed true.

Meanwhile, Weezy remains focused on family and his upcoming #FreeWeezyAlbum:

@LilTunechi: "Reginae's my Super Sweet 16 special will be premiering tonight at 7pm on MTV!!! Don't miss it. Spread the word... Thanx MTV 4 da luv! Nae Nae is my most precious jewel #FWA."